A FRET-Based Ratiometric H2S Sensor for Sensitive Optical Molecular Imaging in Second Near-Infrared Window

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外文摘要：Second near-infrared(NIR-Ⅱ)window optical molecular imaging kicks off a new revolution in high-quality imaging in vivo,but always suffers from the hurdles of inevitable tissue autofluorescence background and NIR-Ⅱ probe development.Here,we prepare a Förster resonance energy transfer-based ratiometric NIR-Ⅱwindow hydrogen sulfide(H2S)sensor through the combination of an H2S-responsive NIR-Ⅱ cyanine dye(acceptor,LET-1055)and an H2S-inert rhodamine hybrid polymethine dye(donor,Rh930).This sensor not only exhibits high sensitivity and selectivity,but also shows rapid reaction kinetics(～20 min)and relatively low limit of detection(～96 nM)toward H2S,allowing in vivo ratiometric NIR-Ⅱ fluorescence imaging of orthotopic liver and colon tumors and visualization of the drug-induced hepatic H2S fluctuations.Our findings provide the potential for advancing the feasibility of NIR-Ⅱ activity-based sensing for in vivo clinical diagnosis.

作者：

Shan Lei、Kejia Jiang、Chenqing Zhang、Wei Sun、Yuantao Pan、Dong Wang、Peng Huang、Jing Lin

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作者单位：

Marshall Laboratory of Biomedical Engineering,International Cancer Center,Shenzhen Key Laboratory of Tumor Visualization Molecular Medicine,Laboratory of Evolutionary Theranostics(LET),School of Biomedical Engineering,Shenzhen University Medical School,Shenzhen University,Shenzhen 518055,China

Center for AIE Research,College of Materials Science and Engineering,Shenzhen University,Shenzhen 518060,China

出版年：

2024

DOI：

10.34133/research.0286

研究(英文)

CSTPCD

ISSN：

年,卷(期)：2024.2024(3)