首页|Access to Axially Chiral Aryl Aldehydes via Carbene-Catalyzed Nitrile Formation and Desymmetrization Reaction

Access to Axially Chiral Aryl Aldehydes via Carbene-Catalyzed Nitrile Formation and Desymmetrization Reaction

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An approach utilizing N-heterocyclic carbene for nitrile formation and desymmetrization reaction is developed.The process involves kinetic resolution,with the axially chiral aryl monoaldehydes obtained in moderate yields with excellent optical purities.These axially chiral aryl monoaldehydes can be conveniently transformed into functionalized molecules,showing great potential as catalysts in organic chemistry.

Yuanlin Cai、Ya Lv、Liangzhen Shu、Zhichao Jin、Yonggui Robin Chi、Tingting Li

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National Key Laboratory of Green Pesticide,Key Laboratory of Green Pesticide and Agricultural Bioengineering,Ministry of Education,Guizhou University,Guiyang 550025,China

National Key Laboratory of Green Pesticide,Key Laboratory of Green Pesticide and Agricultural Bioengineering,Ministry of Education,Guizhou University Guiyang 550025,China

School of Chemistry,Chemical Engineering,and Biotechnology,Nanyang Technological University,Singapore 637371,Singapore

2024

10.34133/research.0293

研究(英文)

研究(英文)

CSTPCD
ISSN：
年,卷(期)：2024.2024(3)