In the post-COVID-19 pandemic era,the long-term surveillance of pathogens is still important.The rapid detection of pathogens facilitates the accurate and convenient real-time monitoring of microbial contamination and improves the management of diseases.Here,a novel surface plasmon resonance(SPR)-based point of care testing(POCT)approach of microorganism nucleic acids with the guidance of CRISPR enzyme is described,including the application of optical fiber-based detection of trace SARS-CoV2 virus in sewage water on SPR and validation of the plasmonic biosensor for the detection of single-nucleotide mutations in natural water samples.
Jing Wang、Zhaojun Duan、Dixian Luo
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Department of Laboratory Medicine,Shenzhen Hospital of Integrated Traditional and Western Medicine,Shenzhen,China
National Institute for Viral Disease Control and Prevention,China Center for Disease Control and Prevention,Beijing,China
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