Taking a central cable plane prestressed concrete cable-stayed bridge project in northwest Hunan as an example,this paper adopts a multi-constraint optimization method to optimize the cable rod's pre-tensioning force of stay cables and enhance the torsional stability of the bridge.Using ANSYS analysis,the traditional method and multi-constraint method are analyzed.The results show that the application of multi-constraint method can effectively reduce the bending moment of the bridge,thereby improving the torsional stability of the bridge.Compared with the traditional method,this method can more effectively adjust the pre-tensioning force distribution of stay cables and reduce the influence of bending moment on the bridge under the premise of ensuring the overall structural stability of the bridge.This study is of great significance to improve the structural performance,safety and reliability of the bridge,and also provides reference for the design and construction of similar engineering in the future.