Based on the engineering background of a(47+47)m skew continuous box-shaped steel-concrete composite beam in Shenzhen Outer Ring Expressway,the single beam model and grillage model are established by Midas Civil finite element software.The changes of structural support reaction force,deformation and longitudinal and transverse stress are compared and analyzed,and the difference in mechanical characteristics between the two models is given.It is concluded that the single beam method can not accurately reflect the difference among the longitudinal beams in the transverse direction.At the same time,the influence of structural design on the change in force on the main beam is analyzed.The conclusion can be used as guidance for the design of the same type of bridges.