Based on the treatment practice of vertical developing silt filling karst mud inrush in newly-built Gaojiaping Tunnel of Zhengzhou-Wanzhou High-speed Railway,this paper studies and reveals the disaster mechanism of karst mud inrush in the tunnel by means of surface investigation,advanced detection at the top and bottom of the tunnel,theoretical analysis and engineering application.The general treatment principle of"adjusting measures to local conditions and zoning treatment"is put forward,and the comprehensive treatment technology system is constructed,which is mainly composed of staged reinforcement and cleaning of mud inrush,advanced pipe roof at the top of the tunnel+reinforced concrete arch protection for strengthening support,and reinforced concrete arch bridge crossing at the bottom of the tunnel,which successfully solves the technical problems of mud inrush treatment in the tunnel.The relevant research results can provide reference and guidance for the treatment of tunnel mud inrush under similar conditions.