摘要
采用中红外(MIR)光谱研究地塞米松棕榈酸酯的分子结构.试验发现,地塞米松棕榈酸酯分子结构的MIR吸收模式主要包括游离O—H基团伸缩振动模式(vO-H-游离-MIR)、缔合O—H基团伸缩振动模式(vO-H-缔合-MIR)、RC＝CH基团C—H伸缩振动模式(vC-H-MIR)、CH2基团不对称伸缩振动模式(vasCH2-MIR)、CH2基团对称伸缩振动模式(vsCH2-MIR)、C＝O基团伸缩振动模式(vC=O-MIR)、RC＝CH基团C＝C伸缩振动模式(vRC=CH-MIR)、CH2基团变角振动模式(δCH2-MIR)、CH3基团对称变角振动模式(δsCH3-MIR)、C—O基团伸缩振动模式(vC-O-MIR)、C—F基团伸缩振动模式(vC-F-MIR)和CH2基团面内摇摆振动模式(ρCH2-MIR).采用近红外(NIR)光谱进一步开展地塞米松棕榈酸酯分子结构的研究.试验发现,地塞米松棕榈酸酯分子结构的NIR吸收模式主要包括游离O—H基团伸缩振动倍频模式(v1-NIR)、缔合O—H基团伸缩振动倍频模式(v2-NIR)、CH2基团对称伸缩振动倍频模式(v3-NIR)、C＝O基团伸缩振动倍频模式(v4-NIR)、CH2基团不对称伸缩振动和CH2基团对称伸缩振动的合频模式(v5-NIR).MIR-NIR光谱联用技术可以有效开展地塞米松棕榈酸酯分子结构的研究.
Abstract
The molecular structure of dexamethasone palmitate was studied using mid infrared(MIR)spectroscopy.The experiment found that the infrared absorption mode of dexamethasone palmitate molecular structure mainly includes free O—H group stretching vibration mode(vO-H-free-MIR),associated O—H group stretching vibration mode(vO-H-associated-MIR),RC=CH group C—H stretching vibration mode(vCH-MIR),CH2 group asymmetric stretc-hing vibration mode(vasCH2-MIR),CH2 group symmetric stretching vibration mode(vsCH2-MIR),C=O group stretching vibration mode(vC=O-MIR),RC=CH group C=C group stretching vibration mode(vc=c-MIR),CH2 group bending vibration mode(δCH2-MIR),CH3 group symmetric bending vibration mode(δsCH3-MIR),C—O group stretching vibration mode(vC-O-MIR),C—F group stretching vibration mode(vC-F-MIR)and CH2 group rocking vibration mode(ρCH2-MIR)The molecular structure of dexamethasone palmitate was further studied using near-infrared(NIR)spectroscopy.The experiment found that the NIR absorption mode of the molecular structure of dexamethasone palmitate mainly includes the free OH groups stretching vibration frequency doubling mode(v1-NIR),associated OH group tretching vibration frequency doubling mode(v2-NIR),CH2 symmetric stretching vibration frequency doubling mode(v3-NIR),C＝O group stretching vibration frequency doubling mode(v4-NIR),the combined frequency mode of CH2 group asymmetric stretching vibration and CH2 group and symmetric stretching vibration(v5-NIR).The MIR-NIR spectroscopy combined technology can effectively carry out molecular structure research on dexamethasone palmitate.
基金项目
石家庄市麻醉药技术创新中心项目(石科[2019]34号)
河北省生物制药国际联合中心项目(冀科外函[2022]3号)
维普
万方数据