Recent Advances on Alkoxy Radicals-Mediated C(sp3)—H Bond Functionalization via 1,5-Hydrogen Atom Transfer
Intramolecular hydrogen atom transfer(HAT)has proved to be an effective method to achieve the selective functionalization of remote C—H bonds.In this fascinating research area,alkoxy radicals have emerged as an important intermediate to participate in intramolecular hydrogen atom transfer reactions.In particular,the burgeoning visible-light photoredox catalysis has provided a new platform for O-radical directed remote functionalization of C(sp3)—H bonds.The progress on the different mechanisms of alkoxy radical generation and their applications in the intramolecular 1,5-HAT reactions for remote C(sp3)—H bond functionalization in the past five years are comprehensively summarized.
visible light photocatalysisalkoxy radicalremote functionalization1,5-hydrogen atom transfer(1,5-HAT)
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