Research Progress in the Synthesis of Benzo[d]pentamembered Heterocyclic Thioethers Containing Two Heteroatoms
The thioether structure of benzo[d]penta-membered heterocycles with double heteroatoms,such as benzo[d]thiazole/oxazole/imidazole,widely exists in many drug molecules and natural product molecules.Its derivatives have extensive biological activities such as antibacterial,antiviral and anti-tumor,and are also important intermediates in organic synthesis and structural units in drug synthesis.Therefore,benzo[d]thiazole/oxazole/imidazole sulfide compounds have great application value in medicine,materials and other fields.The research of its synthesis method has also become one of the current research hotspots.The synthesis methods and biological activity research progress of benzo[d]five membered heterocyclic sulfide compounds with double heteroatoms in recent years are reviewed,and some of their reaction mechanisms are described.
benzo[d]thiazole sulfidebenzo[d]oxazole sulfidebenzo[d]imidazole sulfideC—S bond formationresearch progress
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