羧酸脱羧羟基化反应研究进展
Progress on Decarboxylation and Hydroxylation of Carboxylic Acids
赵红琼 1于淼 1宋冬雪 1贾琦 2刘颖杰 1季宇彬 1许颖1
作者信息
- 1. 哈尔滨商业大学药学院 哈尔滨 150076
- 2. 黑龙江护理高等专科学校 哈尔滨 150086
- 折叠
摘要
羧酸是廉价易得、稳定性好且功能多样的分子,羧酸脱羧羟基化提供了从稳定易得的羧酸原料通过良性单碳切除还原直接快速获得重要醇分子的途径,醇类化合物作为重要功能性分子在各领域的应用随处可见,因此在有机合成和自然界中是一种非常重要和有用的转化.主要从过渡金属催化、光催化、电催化及其他类型催化方面,分类总结了脱羧羟基化反应得到相应伯醇、仲醇和叔醇的研究进展,并探讨了部分反应可能的机理和适用范围.其中过渡金属催化出现较早,生成叔醇产率较高,但底物普适性不强,而光催化反应条件温和,环境污染小,对生成伯仲叔醇均适用.
Abstract
Carboxylic acids are inexpensive,readily available,stable and functionally diverse molecules,and alcohols are used as important functional molecules in a variety of applications.Therefore,decarboxylative hydroxylation of carboxylic acid provides a direct and rapid route to important alcohol molecules from stabilized and easily obtainable carboxylic acid feedstocks through benign single carbon excision reductions,which is a very important and useful transformation in organic synthesis and nature.The research progress on decarboxylative hydroxylation reactions to obtain the corresponding primary,secondary and tertiary alcohols,mainly in terms of transition metal catalysis,photocatalysis,electrocatalysis and other types of catalysis,is highlighted with an emphasis on the possible mechanisms and applicable scope of these different reactions.Among them,transition metal catalysis emerged earlier and produced tertiary alcohols in higher yields,but with less universal sub-strates,whereas photocatalysis is a mild reaction with low environmental pollution and is suitable for the production of prima-ry,secondary and tertiary alcohols.
关键词
羧酸/脱羧羟基化/醇/过渡金属催化/光催化Key words
carboxylic acid/decarboxylation and hydroxylation/alcohol/transition metal catalysis/photocatalysis引用本文复制引用
基金项目
黑龙江省自然科学基金(LH2020H068)
黑龙江省教育厅创新人才项目(UNPYSCT-2018139)
出版年
2024
NETL
NSTL
万方数据