Visible Light-Mediated Selective C—F Bond Cleavage of Trifluoro-methyl Groups and Its Application in Synthesizing gem-Difluoro-Containing Compounds
The unique properties of difluorinated compounds have attracted widespread attention in the fields of medicine and material sciences.The conversion of inexpensive and easily available trifluoromethyl groups into difluoro groups is of great importance in organic synthesis.However,there still exist great challenges in the selective cleavage of C—F bonds,because the dissociation energy of single C—F bond in trifluoromethyl group is much higher thanthat of the C—F bond in the difluoro unit of the generated product.Thus,the selective cleavage of C—F bond is difficult to control,which can easily lead to exces-sive defluorination.Compared with the traditional thermal reaction,the visible-light irradiated reaction provides an alternative pathway to achieve C—F cleavage more efficiently and selectively.The research progress on the selective cleavage of C—F bonds mediated by visible light in the past three years is summarized and its futureperspective is prospected.
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