Palladium-Catalyzed Regioselective Aryl Phenoxylation of Allenamide
A palladium-catalyzed regioselective aryl phenoxylation of allenamide with phenol derivatives has been developed,providing valuable branched allyl ether products in moderate to excellent yields under mild reaction conditions.Importantly,only the proximal addition products of allenamide were observed in the reaction process,and no distal addition products were observed.A coordinated palladium complex was proposed to be responsible for the excellent proximal addition in the insertion step.The final nucleophilic attack at α-position was induced by the steric effect of palladium complex.
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