New Progress of Fully Continuous Flow Reaction Technologies in Pharmaceutical Synthesis(2019～2022)
Continuous flow chemistry is an emerging technology in the chemical pharmaceutical industry.Compared with the traditional batch kettle reaction,continuous flow reaction has the advantages of rapid mass and heat transfer,improves the controllability and safety of the reaction process,and can also integrate the online analysis and purification steps into the flexi-ble operation sequence.The new progress of continuous flow reaction technology in the continuous synthesis process from starting raw material to final active pharmaceutical ingredient(API)from 2019 to 2022 is introduced.Starting from the flow chart of continuous flow reaction,the preparation process and technical advantages of continuous flow reaction are described.At the same time,it is pointed out that the fully continuous flow reaction technology still has some challenges in the process connection and coupling treatment of each single step synthesis transformation,which needs to be further improved.
flow chemistrypharmaceuticalsfully continuous flowsynthetic process
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