Recent Progress on Green Methods and Technologies for Efficient Formation of Amide Bonds
Amide bond constructions are crucial in peptide synthesis and pharmaceutical chemistry research.The traditional methods of peptide synthesis require the use of excessive amounts reagents and solvents,posing a threat to the environment and human health.It is still the current research focus to develop environmentally friendly novel acylation reagents and effi-cient,green,and sustainable amide bond synthesis methods.From the green chemistry's principles,this paper is focused on the efficient formation of amide bonds in peptide,including the catalysis of elemental organic chemicals,some green solvents and reagents,and some physical strengthening methods,etc.The application of these methods and technologies was also discussed in peptide chemistry.
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