利用串联的Staudinger/aza-Wittig/芳构化反应合成1,2,4-三取代咪唑衍生物
Synthesis of 1,2,4-Trisubstituted Imidazoles via Sequential Staudinger/aza-Wittig/Aromatization Reaction
解海 1张雅丽 1秦秀婷 1谷永新1
作者信息
- 1. 山西大同大学化学与化工学院 化学传感山西省重点实验室 山西大同 037009
- 折叠
摘要
报道了一种合成1,2,4-三取代咪唑衍生物的方法,即通过含有烯基叠氮基的苯甲酰胺衍生物为关键中间体,用三苯基膦处理,发生串联的Staudinger/aza-Wittig/芳构化反应,合成得到1,2,4-三取代咪唑衍生物.该反应具有原料廉价易得,反应条件温和,无需使用金属催化剂,操作简便的特点,这是一种理想、高效的1,2,4-三取代咪唑杂环化合物的合成策略.
Abstract
An efficient and convenient route for the synthesis of 1,2,4-trisubstituted imidazole derivatives was described.Benzamide derivatives containing alkenylazide as the basic raw materials were treated with triphenyl phosphorus,and subsequently 1,2,4-trisubstituted imidazole derivatives were synthesized by a sequential Staudinger/aza-Wittig/aromatization reaction.The reaction is characterized by cheap and easy to obtain starting materials,mild reaction conditions,metal-free catalysts,and simple operation.It is an ideal and efficient synthesis strategy of 1,2,4-trisubstituted imidazole heterocyclic compounds.
关键词
Staudinger反应/aza-Wittig反应/芳构化反应/1,2,4-三取代咪唑Key words
Staudinger reaction/aza-Wittig reaction/aromatization reaction/1,2,4-trisubstituted imidazole引用本文复制引用
基金项目
大同市应用基础研究项目(02030710)
出版年
2024
NETL
NSTL
万方数据