Synthesis of 1,2,4-Trisubstituted Imidazoles via Sequential Staudinger/aza-Wittig/Aromatization Reaction
An efficient and convenient route for the synthesis of 1,2,4-trisubstituted imidazole derivatives was described.Benzamide derivatives containing alkenylazide as the basic raw materials were treated with triphenyl phosphorus,and subsequently 1,2,4-trisubstituted imidazole derivatives were synthesized by a sequential Staudinger/aza-Wittig/aromatization reaction.The reaction is characterized by cheap and easy to obtain starting materials,mild reaction conditions,metal-free catalysts,and simple operation.It is an ideal and efficient synthesis strategy of 1,2,4-trisubstituted imidazole heterocyclic compounds.
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