Amide Hydrolysis Reaction Using tert-Butyl Nitrite
Amide is a compound that serves important functions and acts as versatile synthons,finding wide applications in organic synthesis and pharmaceutical chemistry.In this study,the mild hydrolysis reaction of primary amides using tert-butyl nitrite is showed,which leads to the formation of diverse carboxylic acids.This method stands out because it operates under neutral conditions,has a wide range of applicable substrates,and is compatible with various functional groups.
NETL
NSTL
万方数据
