Application of α-Cyanohydrin Methanesulfonates for the Synthesis of α-Aminonitriles
An efficient synthesis of α-aminonitriles via nucleophilic substitution of α-cyanohydrin methanesulfonates with aromatic amines was developed.This transition metal-free protocol has the advantages of cheap and easily available starting materials,broad substrate scope,excellent functional group compatibility,and very mild and simple operations.Furthermore,this strategy could also be applicable to quaternary α-cyanohydrin methanesulfonates and various nitrogen nucleophiles.A range of derivatives were readily obtained through subsequent elaboration of α-aminonitriles.
NETL
NSTL
万方数据
