Regio-and Stereo-selective Synthesis of 1β-/3R-Aryl Thiosugar
Thiosugars have attracted much attention in the field of pharmaceuticals because of their excellent biological activ-ities,and chemical synthesis is an important way to obtain thiosugars.Using 6-O-diphenylphosphoryl-3,4-O-carbonate-D-gala-ctal and thiophenols as starting materials,the regio-and stereo-selective syntheses of 1β-/(3R)-aryl thiosugars were controlled with NiBr2 and Pd2(dba)3 catalysts,respectively.The structures of the target compounds were characterized by nuclear mag-netic resonance,high-resolution mass spectrometry and single crystal X-ray diffraction.This method exhibited favourable compatibility with various functional groups substituted thiophenols,which could be used for the structural modification of active natural products.The research work is help for the rapid construction of the compound library of 1β-/(3R)-aryl thio-sugars for drug discovery.
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