Synthesis of 4-Methyl-2-oxo-6-arylamino-2H-pyran-3-carbonitrile Derivatives
2-Pyrone derivatives have demonstrated considerable potential for usage in the field of medicine.Many of these skeleton structures have been used as precursors in the synthesis of pharmacologically active molecules.As a result,it is criti-cal to explore new approaches for the synthesis of 2-pyrones.A series of 2-pyrone derivatives were synthesized from β-oxo amides and ethyl cyanoacetate through one-step reaction.The methodology offers several significant advantages including mild conditions,ease of handling,and high yields(82％～93％).Such,an efficient synthesis approach for 2-pyrones is provid-ed.
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