电化学不对称合成反应的研究进展

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中文摘要：不对称合成是有机化学最重要和最有价值的前沿领域之一。近年来，随着有机电化学的复兴和蓬勃发展，利用电化学的优势，拓展不对称催化的反应类型、活化模式、成键体系以及底物的适用范围，为完成传统化学难以实现或者无法实现的不对称转化带来新的契机。因此，发展新型、高效、精准和可持续的电化学不对称合成策略，具有重要的研究意义。尽管具有诸多优势并取得了关键进展，不对称电化学合成依然极具挑战性，高对映选择性电化学转化的例子报道相对较少。近年来，国内外有机化学领域的学者们在电化学不对称催化领域开展了一系列原创性的研究工作，取得了令人瞩目的成果。全面梳理了过渡金属、有机小分子、生物酶、手性电极、手性电解质、手性溶剂和手性辅助剂参与的不对称电化学合成及其相关的反应机理;概述了不对称有机电化学合成领域的理论创新、技术突破和困难挑战;并展望了该领域的未来发展趋势。

外文标题：Advances in Asymmetric Electrochemical Synthesis

外文摘要：Asymmetric synthesis is one of the most important and valuable frontiers in exploratory research of synthetic organic chemistry.With the renaissance and vigorous development of organic electrochemistry in recent years,combining electrochemical organic synthesis and asymmetric catalytic strategies can be used to expand the reaction types,activation modes,bond formation systems,and substrate adaptability of asymmetric catalysis using the benefits of organic electrochemistry,which brought new opportunities for the asymmetric transformation that is difficult or impossible to be achieved by traditional methods.Thus,the development of novel,efficient,precise and sustainable electrochemical asymmetric catalytic strategies under mild and eco-friendly conditions is of great research significance.Although there are many advantages and key advances in asymmetric electrocatalysis,major challenges remain.Until now,relatively few examples of asymmetric electrochemical transformations with high enantioselectivity have been reported.In recent years,scholars in the field of organic chemistry around the world have carried out a series of original works in the field of asymmetric electro-chemical catalysis,and achieved remarkable results.The theoretical innovation,technical breakthrough,and difficult challenges in asymmetric electrochemical synthesis in recent decades are summarized.Examples of enantioselective electro-organic synthesis using transition metal catalysts,organocatalysts,biological enzyme catalysts,chemically modified chiral electrodes,chiral electrolytes,chiral solvents and chiral auxiliaries are discussed,along with their related reaction machanistic aspects.Finally,perspectives on this cutting-edge area are also briefly discussed.

外文关键词：

organic electrosynthesisasymmetric catalysisenantioselectivitytransition-metal catalysisorganocatalysis

作者：

高淳、刘欣、王明慧、刘淑贤、朱婷婷、张怡康、郝二军、杨启亮

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作者单位：

河南师范大学化学化工学院抗病毒性传染病创新药物全国重点实验室平原实验室绿色化学介质与反应教育部重点实验室精细化学品绿色制造河南省协同创新中心河南新乡 453007

关键词：

有机电合成不对称催化对映选择性过渡金属催化有机催化

基金：

国家自然科学基金河南省自然科学基金河南师范大学科研启动经费项目大学生创新创业训练计划大学生创新创业训练计划

项目编号：

220070282323004211265101039170920202310476058202310476055

出版年：

2024

DOI：

10.6023/cjoc202402005

有机化学

中国化学会,中国科学院上海有机化学研究所

有机化学

CSTPCD北大核心

影响因子：1.09

ISSN：0253-2786

年,卷(期)：2024.44(3)

参考文献量203