Electrochemical Oxidation Decarboxylative Cyclization of α-Keto Acid with o-Aminobenzylamine
A novel method for synthesizing quinazolines by an electrochemical oxidation decarboxylative cyclization reaction of α-keto acid with o-aminobenzylamine under metal and external chemical oxidants free conditions was developed.This method has mild reaction conditions,and can tolerate a wide range of functional groups,and can provide the corresponding products with moderate to excellent yields.Furthermore,the method can also be used for the synthesis of other heterocycles such as benzoxazole,benzothiazole and benzimidazole.
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