Electrocatalysis Decarboxylative Annulation of Benzol[e][1,2,3]-oxathiazine-2,2-dioxides with N-Arylglycines
Benzo[e]imidazo[1,2,3]oxathiazine-5,5-dioxides are a significant class of fused N-heterocycles,possessing diverse biological and pharmacological activities.In this paper,a novel method for the synthesis of benzo[e]imidazo[1,2,3]oxathia-zine-5,5-dioxides through electrochemical cascade decarboxylative coupling/annulation of benzol[e][1,2,3]oxathiazine-2,2-dioxides with N-arylglycines was reported.A wide variety of benzo[e]imidazo[1,2,3]oxathiazine-5,5-dioxides were effi-ciently constructed in good to excellent yields.This strategy offers notable benefits,such as gentle and environmentally friendly conditions,operational simplicity,impressive yields,excellent tolerance towards various functional groups,and straightforward scalability,making it highly valuable for practical applications.
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