基于指示剂置换法的大环荧光传感平台的构建及应用研究进展
Research Progress on the Construction and Application of Macrocyclic Fluorescent Sensing Platform Based on Indicator Displacement Assay
谌泽亚 1李诗瑶 1杨留攀 1王力立 1姚欢1
作者信息
- 1. 南华大学药学院 湖南衡阳 421001
- 折叠
摘要
超分子荧光传感器可以解决与环境及人类健康相关的检测和成像问题.指示剂置换法(IDA)是一种能够将分子识别所引起的化学变化转化为易于观察的荧光信号的超分子荧光传感方法,为分析物的检测提供了独特且创新的传感策略.近年来,由于其灵敏度高、可调节、实时和无需复杂合成的优点,基于非共价结合的IDA得到了快速的发展.为了满足IDA发展的多样化需求,超分子科学家们引入了各种超分子大环主体,如杯[n]芳烃、葫芦[n]脲及柱[n]芳烃等.根据大环进行分类,对近些年该领域的研究进展进行简要综述,重点关注在生化传感方面的应用,为今后基于IDA的新型荧光生化传感平台的构建及应用提供参考.
Abstract
Supramolecular fluorescent sensors can address various detection and bioimaging issues related to the environment and human health.Indicator displacement assay(IDA)is a supramolecular fluorescence sensing method that can convert the chemical changes caused by molecular recognition into easily observed fluorescence signals.It provides a unique and innovative sensing method for the detection of analytes.In recent years,IDA based on non-covalent binding has been developed rapidly due to its advantages of high sensitivity,adjustability,real-time,and low synthesis effort.In order to meet the diverse needs of IDA development,a variety of supramolecular macrocyclic hosts have been involved in the construction of IDA sensors,such as calix[n]arenes,cucurbit[n]uril,pillar[n]arenes,etc.The recent research progress in this field based on different classes of macrocycles is briefly reviewed,focusing on the application in biochemical sensing,and providing a reference for the construction and application of novel fluorescent biochemical sensing platforms based on IDA in the future.
关键词
指示剂置换法/超分子化学/主-客体相互作用/大环主体Key words
indicator displacement assay/supramolecular chemistry/host-guest interaction/macrocyclic host引用本文复制引用
基金项目
国家自然科学基金(22174059)
国家自然科学基金(22201128)
湖南省自然科学基金(2022JJ40363)
湖南省自然科学基金(2022JJ40365)
湖南青年科技创新计划(2022RC1230)
中国博士后科学基金(2022M721542)
出版年
2024
NETL
NSTL
万方数据