Silver-Catalyzed 5-Exo-dig Cyclization Reaction of ortho-Hydroxyphenylpropargyl Alcohols to 2-Methylene-2,3-dihydrobenzofuran
2-Methylene-2,3-dihydrobenzofuran derivatives,as one of the core skeletons of various natural products and drugs,are of great significance in finding new methods for effectively synthesizing 2-methylene-2,3-dihydrobenzofuran from easily available raw materials.Herein,a novel silver-catalyzed 5-exo-dig cyclization reaction of orth-hydroxyphenyl alkynyl alcohols has been developed,providing an efficient and modular method for the construction of 2-methylene-2,3-dihydrobenzofuran.Featuring the advantages of mild conditions,simple operation,and high efficiency,the reaction requires the utilization of 2 mol％of silver carbonate as a catalyst and 5 mol％of isocyanide as a ligand at room temperature.
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