Construction of a Lipid Droplets Targeted Fluorescent Probe for Visualization of Liver Tumor Cells
Lipid droplets(LDs)are involved in the metabolic processes of many living cells,and their anomalies are highly associated with a variety of diseases,such as fatty liver,diabetes and cancers.But it is still a great challenge to elucidate the intrinsic relationship between various diseases and LDs.In particular,there has been only a few studies on the visualization of abnormal LDs in liver tumor cells.Therefore,in this paper,a lipid droplets targeted fluorescent probe was easily prepared through a two-step procedure by using triphenylamine as the electron donor and polycyanide heterocyclic compound as the electron acceptor.The fluorescent probe TCN-Tph possesses good ability to target LDs in living cells through their co-localization imaging experiments.In comparison with other carcinoma cells,the liver tumor cells have good response and uptake of TCN-Tph.The slices images of liver tissues in different states further show that the probe TCN-Tph can also distinguish liver tissues and normal liver tissues effectively,which provide an experimental basis for the early diagnosis of liver tumor cells in clinic.
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