摘要
提出了一种新的非活化烯烃、喹喔啉酮和AgSCF3的三组分级联自由基反应.在氧化剂K2S2O8的作用下,得到了 40个含SCF3的喹喔啉酮类衍生物,其中产率最高至78％.该方法是一种在温和条件下制备含三氟甲硫基喹唑啉酮类化合物,具有产率高、底物范围广、原子经济性高和环保高效等优势.
Abstract
A novel three-component cascade radical reaction involving non-activated olefins,quinoxalin-2(1H)-ones,and AgSCF3 was proposed.Under the action of the oxidizing agent K2S2O8,40 quinoxaline derivatives containing SCF3 were obtained with the highest yield of 78％.This method provides a mild and environmentally friendly approach to prepare trifluoromethylthio-substituted quinoxalines,offering advantages such as high yield,broad substrate scope,atom economy,and environmental efficiency.
基金项目
浙江省先进化工制造技术重点实验室项目(2017E10001)
NETL
NSTL
万方数据