Three-Component Reaction Involving Alkenes,AgSCF3 and Quinox-alinones Initiated by Trifluoromethylthio Radical
A novel three-component cascade radical reaction involving non-activated olefins,quinoxalin-2(1H)-ones,and AgSCF3 was proposed.Under the action of the oxidizing agent K2S2O8,40 quinoxaline derivatives containing SCF3 were obtained with the highest yield of 78％.This method provides a mild and environmentally friendly approach to prepare trifluoromethylthio-substituted quinoxalines,offering advantages such as high yield,broad substrate scope,atom economy,and environmental efficiency.
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