Catalyst-and Additive-Free Direct Synthesis of N-Sulfonyl Guanidines
A simple and direct method for the synthesis of N-sulfonyl guanidines from sulfonamide and carbodiimides under catalyst-and additive-free conditions was demonstrated.This method has the advantages of no catalyst and additive required,simple operation,good functional group compatibility,a wide range of substrate applications,high yield,high atomic econo-my,and the ability to scale up proportionally.It provides a facile and efficient strategy for the preparation of N,N',N"-trisub-stituted sulfonyl guanidines.
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