Visible-Light-Induced C—C Bond Cleavage of Dihydroquinazolinones with Trifluoromethyl-Substituted Olefins Defluorinated Alkylation Reactions
The visible-light-induced C—C bond cleavage of dihydroquinazolinone to generate alkyl radicals for defluorinated alkylation reactions with α-trifluoromethyl alkene is reported.The method is featured as transition-metal-free,mild conditions,base-or additive-free,and has a wide range of substrate applicability,which provides a convenient and efficient new method for the synthesis of various alkyl-substituted gem-difluoroalkene.
visible-light catalysisdihydroquinazolinoneC—C bond cleavagegem-difluoroalkeneα-trifluoromethyl alkene
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