Synthesis and Anti-porcine Pseudorabies Virus(PRV)Activity of Novel N-Pyridinium Bipyrazole Dimer Derivatives
The porcine pseudorabies virus(PRV)leading to severe neurological and respiratory damage can infect a wide range of vertebrates and humans,which raises concerns regarding the potential cross-species transmission of PRV.However,there is currently a lack of specific antiviral treatments available for PRV.25 dimer derivatives containing N-pyridine bipyra-zole moiety were designed and synthesized based on the principles of molecular splicing and electron isoarrangement.The inhibitory effect of the target compounds on PRV virus was assessed.Preliminary bioassay revealed that most of the com-pounds exhibited potent anti-PRV activity at a concentration of 10 μmol/L while demonstrating no or minimal toxicity towards a type of porcine kidney cell(PK-15).These novel N-pyridinium bipyrazole dimer derivatives could be regarded as anti-PRV agents for further optimization and development.
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