Regioselective C(2)Methylthiolation and d3-Methylthiolation of Indoles Based on Dimethyl Sulfoxide(DMSO-d6)Reagents
Cu(OAc)2 mediated C(2)-selective d3-methylthiolation and methylthiolation of indoles were developed.With the choice of dimethyl sulfoxide(DMSO)as sulfur source and solvent,methylthiolation reaction could be achieved in moderate to good yields,and d3-methylthiolated products could also be obtained with DMSO-d6 as reagent just by prolong the reaction time.Moreover,this methylthiolation didn't depend on high temperature,and radical pathway might be involved in this trans-formation.
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