Recent Progress in Radical Involved Alkene Dialkylation
Difunctionalization of alkenes constitutes a critical route for alkene derivatization and construction of molecular complexities.Yet dialkylation of alkenes allows the continuous construction of two new C(sp3)—C(sp3)bonds which is one of the most effective ways for functional alkane synthesis.Because of the high reactivity of alkyl reagents,problems such as poor regioselectivity and side reactions always appear in alkene alkylation process.In recent ten years,with the further development in radical mediated reactions,significant progress has been seen in difunctionalization of alkenes through radical path.Howev-er,challenges still exist in the implement of high selectively dialkylation of alkenes.This review aims to give a comprehensive overview about the radical involved alkene dialkylated reaction.The regioselectivity control of this reaction is elaborated from three different reaction modes:intramolecular cyclization-intermolecular alkylation,alkyl radical addition-1,2-migrated alkyla-tion of alkenyl boron ate complexes and three-components reaction of alkenes with disparate alkylated reagents.
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