Recent Advances in Strategies for Halide Atom Transfer(XAT)and Their Applications
Following the rapid advance of radical chemistry,a range of halogen atom transfer(XAT)reagents have been de-veloped by chemists for alkyl and aryl halides,which typically feature strong bond strengths and high redox potentials.These reagents facilitate the extraction of halogen atoms from alkyl and aryl moieties via radical substitution pathways,thus generat-ing radical species that undergo subsequent chemical transformations for the synthesis of valuable molecules.The unique reac-tivity and versatility of these XAT reagents have attracted much attention in organic synthesis.Recent reviews of XAT reagents have mainly focused on elucidating reaction mechanisms and classifying different types with limited exploration of activation strategies.In light of this,this paper provides a summary of the activation strategies for XAT reagents over the past three years.The discussion is organized into four aspects based on different strategies,namely single electron transfer,hydrogen atom transfer,energy transfer,and electron donor-acceptor(EDA)complexes.This review aims to address the research gaps in acti-vation strategies of XAT reagents,providing new theoretical support and perspectives for the field.
halogen atom transfersingle electron transferhydrogen atom transferenergy transferelectron donor-acceptor(EDA)complex
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