Research Progress of Tetralactam Macrocycle-Based Molecular Recognition and Applications
Molecular recognition is ubiquitous in nature and plays a crucial role in numerous biological processes and supramolecular chemistry.Due to the significant weakening of specific non-covalent interactions(e.g.,hydrogen bonding)by the polar environment of water,the use of artificial macrocyclic hosts for molecular identification in the water is challenging.Tetralactam macrocycles are artificial macrocyclic hosts with polar binding sites inside the hydrophobic cavity,which can realize the recognition of hydrophilic molecules in the water by mimicking the molecular recognition of bioreceptors.Through the synergistic effect of hydrophobic effect and hydrogen bonds,it can selectively recognize drug molecules,saccharides,dyes,organic pollutants,disease markers and other substances in the aqueous environment.The research advances of tetralactam macrocycles in molecular recognition and application over the last 30 years are summarized,with a particular emphasis on its molecular recognition and application in the water,hoping to provide a reference for the development of tetralactam macrocycles in the future.
supramolecular chemistrytetralactam macrocyclemolecular recognitionhydrogen bond
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