Research Progress on the Hydroamination of o-Alkynylanilines for the Synthesis of Axially Chiral Indoles
Hydroamination of o-alkynylanilines is an important approach for the synthesis of indoles.On this basis,o-alkynylanilines bearing substituents with certain steric hindrance could undergo chiral transition-metal catalyzed or organo-catalytic atroposelective 5-endo-dig cyclolization for the synthesis of axially chiral indoles.Classified by the types of chiral axes in the products of enantioselective hydroamination,the catalytic enantioselective methods for the preparation of axially chiral indoles containing C—N,C—C and N—N chiral axes are systematically introduced.
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