Nickel-Catalyzed Reductive anti-Arylative Cyclization of 1,6-Enynes with Aryl Halides
A nickel-catalyzed reductive trans-arylative cyclization of 1,6-enynes with aryl halides has been developed.This transformation avoids the use of stoichiometric organometallic reagents and features mild conditions,good functional group tolerance and broad substrate scope.This method serves as an efficient platform for the synthesis of various carbo-and heterocycles,which are abundant in many natural products and biologically active compounds.
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