Heterogeneous Iron-Catalyzed Oxyalkylation of Vinylarenes via C(sp3)—H Activation of Cyclic Ethers
Alkene difunctionalization is an important route to construct new chemical bonds over the olefin double bond,oxyalkylation reaction of olefins will provide C—C bond and C—O bond forming products.The current oxyalkylation meth-ods rely in employing tert-butyl hydroperoxide as the oxidant.Therefore,developing an aerobic oxidation system for this transformation is highly desired.Herein,an unprecedented heterogeneous iron catalyzed oxyalkylation of styrene derivatives under mild conditions was reported,using air as oxidant and oxygen source.Detailed catalyst characterization,substrate scope and mechanistic studies were carried out and a proposed mechanism was given.
alkenedifunctionalizationC(sp3)—H activationheterogeneous iron catalysis
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