Direct Sulfonylation of Pyrazolones with Sulfonyl Chlorides to Synthesize Pyrazolyl Sulfonates
Pyrazole as a core framework exists in many bioactive molecules and has a wide range of applications in pharma-ceuticals,agricultural chemicals and other functional materials.Sulfonates are important intermediates in organic synthesis and play a very important role in organic chemistry.A green and efficient method for the synthesis of pyrazolyl sulfonate com-pounds by using pyrazolones and sulfonyl chlorides as starting materials was developed.This method features the advantages of simple and easy to operate,without the need for any additives,metal or oxidant.It only requires room temperature and wa-ter as the solvent to efficiently synthesize important pyrazolyl sulfonates.The smooth progress of the gram scale reaction and product transformation further proves the practicality of this method.
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