Functionalized carbo-and hetero-cyclic compounds are widely found in natural products and other bioactive molecules,which are also important scaffolds with significant synthetic value.The cyclization of 1,n-enynes is one of the most atom-economic and efficient approaches.In particular,the palladium-catalyzed cyclization of 1,6-enynes has been extensively studied and has achieved significant advancements.This review focuses on the cyclization of 1,6-enynes initiated by nucleopalladation of alkynes,including hydropalladation,carbopalladation,halopalladation and oxypalladation.It was classified by the nucleopalladation and the recent developments in palladium-catalyzed 1,6-enyne cyclization over the past two decades are systematically summarized.Special emphasis is placed on the asymmetric reactions,and reaction mechanisms,along with further prospects of this field.
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