水溶液中的Minisci反应研究进展
Recent Advances of Minisci Reactions in Aqueous Solution
王文贵 1王守锋1
作者信息
- 1. 济南大学化学化工学院 山东省氟化学化工材料重点实验室 济南 250022
- 折叠
摘要
Minisci反应是通过自由基中间体对缺电子含氮杂环化合物进行官能团化的方法.利用Minisci反应可以向未官能团化的缺电子含氮杂环上引入烷基、酰基、硅基、烷硫基、硼烷等,构建具有不同取代基的杂环化合物,是合成取代杂环的一个重要手段.水作为一种绿色环保的溶剂,是进行有机反应的理想介质,在Minisci反应中得到了广泛应用.尽管从发现Minisci反应开始,水作为Minisci反应的介质就得到应用,但是水溶液中的Minisci反应仍然发展缓慢.从烷基化、芳基化和酰基化三个方面,根据不同的自由基前体,综述了水溶液中Minisci反应的进展.
Abstract
Minisci reaction is a convenient method for the functionalization of C—H in electron-defficient N-heterocycles.Different substituents could be introduced onto heterocycles through Minisci reaction,such as alkyl,acyl,silyl and alkylthio,etc.Water is eco-friendly and an ideal medium in organic synthesis,which has been applied in Minisci reaction.Recent progress in Minisci reaction in aqueous solution is reviewed herein.Minisci reaction is a convenient method for the functionalization of electron-defficient N-heterocycles.Different substituents could be introduced onto heterocycles through Minisci reaction,such as alkyl,acyl,silyl and alkylthio,boryl,etc.Thus,Minisci reaction is a powerful toolbox for the synthesis of substituted N-heterocylces.Water is eco-friendly and an ideal medium in organic synthesis,which has been applied in Minisci reaction.Although water was used from the discovery of Minisci reaction,Minisci reaction in aqueous solution is still underdeveloped.The recent progress in Minisci reaction in aqueous solution,including alkylation,arylation and acylation,is reviewed according to different radical precursors.
关键词
Minisci反应/自由基/水溶液/杂环化合物Key words
Minisci reaction/radical/aqueous solution/heterocycie引用本文复制引用
出版年
2024
NETL
NSTL
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