Metal-Free 1,8-Diazabicyclo(5.4.0)-undec-7-ene Mediated Synthesis of α-Acetal Amides through Reaction of Glyoxylic Acid Acetalde with Aryl Isothiocyanates
Metal-free condensation reaction of glyoxylic acid acetalde with aryl isothiocyanates leading to α-acetal amides has been reported.The present protocol,which simply utilizes 1,8-diazabicyclo(5.4.0)-undec-7-ene(DBU)as base,provides a green and efficient approach to construct a series of α-acetal amides in the absence of metal catalysts and stoichiometric amounts of coupling reagents.
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