One Pot Tandem P-Michael Addition/SN2/lntramolecular Wittig Reaction of aza-o-Quinone Methides:Construction of 2,3-Disubstituted Dihydroquinoline Derivatives
A one-pot tandem P-Michael addition/SN2/intramolecular Wittig Reaction of in situ generated aza-o-quinone methides with PPh3 and α-bromo ketones has been reported.This protocol provided an efficient and mild approach to synthesize 2,3-disubstituted dihydroquinolines in 25％～93％yields.In addition,the 2,3-disubstituted quinolines could also be obtained by simply modification of the reaction conditions.
NETL
NSTL
万方数据
