Synthesis of 3,5-Diaryl-1,2,4-oxadiazole by One-Pot Homocoupling Reaction
3,5-Diaryl-1,2,4-oxadiazoles were synthesized by homocoupling of chloroarylaldoxime from arylaldoxime and N-chlorosuccinimide(NCS)in the presence of Cs2CO3 in one pot.The method is suitable for thiophene-3-carbaldehyde,ison-icotinaldehyde and arylaldehyde without active substituent with a yield from 19％to 78％.However,it was not suitable for aliphatic aldehydes,other heteroaromatic aldehydes and benzaldehydes carrying active groups(hydroxyl,amino and carbox-ylic acid).Compared to reported methods,this method uses only aromatic aldoxime as a single substrate.The process is sim-ple,convenient,and green,making it a reliable way to synthesize 3,5-(homo-substituted)-1,2,4-oxadiazoles.
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