Manganese-Catalyzed Ring-Opening C—C Bond Fluorination of Cyclobutanols
Manganese-catalyzed C—C bond cleavage of cyclobutanols has attracted great attention due to the high abundance and cheap and eco-friendly behaviour.A manganese-catalyzed ring-opening C—C bond fluorination of cyclobutanols is reported.Under mild conditions,the reaction provides a straightforward access to y-fluorinated ketones using 10 mol%Mn(OAc)2 as catalyst and electrophilic fluorination reagent,which was generated in situ from HF·Et3N and PhIO,as fluorine source.The reaction has an excellent functional-group tolerance and displays a broad substrate scope,affording the corresponding products in 50%~76%yields.
manganese catalysisC—C bond functionalizationcyclobutanolfluorinationy-fluorinated ketone