o-lodoarylation of Thiols Enabled by Aryne Generated from o-Diiodoarene and Sodium Hydride
A simple and efficient method is described for the synthesis of o-iodoaryl thioethers by the reaction of thiols and aryne.The aryne is generated from inexpensive and readily available reagents o-diiodoarene and sodium hydride.Remarkably,no disulfide substituted byproduct was observed in the reactions which is different from transition metal-catalyzed process.This method features simple operation,mild reaction conditions,broad substrate scope,and high reaction yields for many cas-es.
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