Study on Isolation,Identification and Bioactivity of Desferrioxamine E and Its Metal-Complexes from Streptacidiphilus jiangxiensis
Research on the genus Streptacidiphilus was mainly focused on the isolation and identification of new species,with relatively less emphasis on the study of secondary metabolites.A new aluminium-complex alumioxamine(3),and two known compounds desferrioxamine E(1)and ferrioxamine E(2)were isolated from the fermentation broth of Streptacidiphi-lus jiangxiensis CGMCC 4.1857.Their structures were elucidated by MS,IR,NMR and single crystal X-ray diffraction tech-nologies.Structurally,compound 3 features aluminum(Ⅲ)as the central atom,which is bonded to six oxygen atoms of the ligand,forming a hexadentate complex.Furthermore,in vitro cytotoxicity assays showed that compound 1 exhibited potential inhibitory activity against four human tumor cell lines(Hela,PANC1,A375 and MHCC-97H)at a concentration of 100 μmol/L with cell viability ranging from 4.8％to 66.4％.
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