聚集诱导发光材料在肿瘤光治疗应用中的最新进展
Recent Progress of Aggregation-Induced Emission Materials in Tumor Phototherapy
孟子翔 1田秀梅 1张天富1
作者信息
- 1. 广州医科大学生物医学工程学院 广州 511400
- 折叠
摘要
癌症是世界上导致死亡的主要原因之一,其发病率不断上升.光疗以其无创、无耐受性、副作用小和操作方便等优势,已成为癌症精准治疗的新范式.自2001年唐本忠院士团队发现聚集诱导发光(AIE)现象以来,具有该性质的荧光材料被广泛用作高效光敏/光热试剂.因其高度扭曲的分子结构,避免了聚集态下的平面堆叠问题,从根本上解决了传统荧光材料聚集淬灭现象,显著提高了量子产率和光稳定性.作者详细对AIE材料作为光敏剂、光热剂及显影剂在癌症光疗(光动力治疗、光热治疗和光声成像)以及联合治疗中的最新应用进行了综述,并展望其未来发展趋势.
Abstract
Cancer is a leading cause of death globally with its incidence rate on the rise.Phototherapy has emerged as a novel approach for precise cancer treatment,offering benefits such as non-invasiveness,no drug resistance,minimal side effects,and ease of operation.Since Prof.Ben Zhong Tang conceptually coined aggregation-induced emission(AIE)in 2001,AIE materials have been extensively applied as efficient photosensitive and photothermal agents.Thanks to their highly twisted molecular structure,AIE materials avoid the issue of π-π stacking in aggregated states,thereby fundamentally addressing the aggregation-caused quenching problem observed in traditional fluorescent materials.This advancement leads to a significant enhancement in quantum yield and photostability.Herein,the author comprehensively reviews the latest applications of AIE materials as photosensitizers,photothermal agents,and diagnostic agents in cancer phototherapy.
关键词
聚集诱导发光/光动力治疗/光热治疗/多模态联合治疗Key words
aggregation-induced emission/photodynamics therapy/photothermal therapy/multimodal combination therapy引用本文复制引用
出版年
2024
NETL
NSTL
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