氢原子转移介导的烷烃C(sp3)—H选择性官能团化研究进展
Recent Advances in Hydrogen Atom Transfer Induced Selective C(sp3)—H Functionalization of Alkanes
王淼 1黄雅豪 1胡鹏1
作者信息
- 1. 中山大学化学学院 绿色化学与分子工程研究所 广东省高等学校功能分子工程基础研究卓越中心Lehn功能材料研究所 广州 510275
- 折叠
摘要
作为一种高度原子经济性和步骤经济性的策略,通过烷烃C(sp3)—H键的官能团化,直接将烷烃转化成附加值更高的化学品,一直备受关注.然而由于烷烃C(sp3)—H键广为人知的惰性,控制非活化C(sp3)—H键官能团化的化学选择性和区域选择性是一项重大的挑战.作为一种近期重新引起关注的方法,相比以往过渡金属催化,利用氢原子转移(HAT)实现C(sp3)—H键选择性官能团化有着其独特之处.在此,对最近兴起的各种HAT介导的非活化C(sp3)—H键官能团化的方法进行了分析,按照官能团化的选择性分类,重点介绍了目前实现区域选择性控制的方法.最后总结了目前方法的局限性,并对这一领域当前的挑战和未来的发展方向进行了展望.
Abstract
As a highly atom-economical and step-economic strategy,the functionalization of alkane C(sp3)—H bonds to di-rectly convert alkanes into higher value-added chemicals has been a subject of great interest.However,due to the well-known inertness of alkane C(sp3)—H bonds,controlling the chemical selectivity and regioselectivity of non-activated C(sp3)—H bond functionalization poses a significant challenge.Recently,the utilization of hydrogen atom transfer(HAT)for achieving selec-tivity in C(sp3)—H bond functionalization has attracted renewed attention as a method distinct from traditional transition met-al-catalyzed approaches.Herein,various HAT-mediated non-activated C(sp3)—H bond functionalization methods are analyzed based on selectivity of functionalization with a focus on methods that have achieved regioselectivity control.The current limi-tations of existing methods are summarized and the current challenges and future directions in this field are outlooked.
关键词
氢原子转移/非活化C(sp3)—H键/C(sp3)—H键官能团化/区域选择性/烷烃Key words
hydrogen atom transfer/unactivated C(sp3)—H bond/C(sp3)—H functionalization/regioselectivity/alkane引用本文复制引用
出版年
2025
NETL
NSTL
万方数据