Objective To compare the difference of antibacterial activity of Lonicera Japonica Thunb a-gainst Methicillin-sensitive Staphylococcus aureus(MSSA)and Methicillin-resistant Staphylococcus aureus(MRSA)in vitro.Methods Thirty strains of MSSA and MRSA were collected and identified by Cefoxitin screening test and mecA gene detection,respectively.The agar punch method was used to detect the antibacte-rial activity of Lonicera Japonica Thunb against two types of Staphylococcus aureus and compared their differ-ences.Agar dilution method was used to detect the MIC of Lonicera Japonica Thunb against two types of Staphylococcus aureus,and the MIC50 was calculated.Results Lonicera Japonica Thunb had in vitro antibac-terial activity against both MSSA and MRSA with MIC50 of 3.125 mg/mL.Conclusion Lonicera Japonica Thunb has a good antibacterial activity against both MSSA and MRSA in vitro,and has great application pros-pect in the clinical treatment of Staphylococcus aureus infection.
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