Study on the correlation between 24-hour pulse pressure,pulse pressure index,ApoE genotype frequency distribution and cerebral microhemorrhage in the elderly population
Study on the correlation between 24-hour pulse pressure,pulse pressure index,ApoE genotype frequency distribution and cerebral microhemorrhage in the elderly population
Objective To investigate the relationship between 24-hour pulse pressure,pulse pressure in-dex,ApoE genotype frequency distribution,and cerebral microhemorrhage in the elderly patients with ischemic cerebrovascular disease.Methods A total of 146 patients with ischemic cerebrovascular disease were admit-ted in the Department of Neurology at Bengbu Third People's Hospital Affiliated with Bengbu Medical Univer-sity from July 2022 to July 2023.The patients were divided into two groups based on the detection results of susceptibility weighted imaging(SWI):the non-CMBs group and the CMBs group.We collected and recorded the clinical data,the 24-hour pulse pressure,the pulse pressure index and ApoE gene polymorphism of all en-rolled patients.Results The study found significant differences between the non-CMBs group and the CMBs group in terms of 24-hour pulse pressure,pulse pressure index,ApoE genotype,and allele frequency distribu-tion(P＜0.05).The logistic regression analysis showed that ε4 allele carrying(OR=5.321,95％CI:1.849～15.318)and 24-hour pulse pressure(OR=1.086,95％ CI:1.031～1.143)were risk factors for cerebral microbhemorrhage in elderly patients with ischemic cerebrovascular disease.The e4 allele carrying group had an increased incidence of microbleeding in the lobar and deep/subtentorial groups.Additionally,a wide 24-hour pulse pressure increased the incidence of CMBs in the deep/subtentorial groups.Conclusion In elderly pa-tients with ischemic cerebrovascular disease,cerebral microhemorrhage is associated with 24-hour pulse pres-sure,pulse pressure index and ApoE genotype frequency distribution.The e4 allele carrying and 24-hour wide pulse pressure increase the risk of cerebral microhemorrhage.
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