Expression and prognostic significance of TSPAN9 in cervical squamous cell carcinoma:A bioinformatics analysis
Objective To analyze the expression and prognostic significance of TSPAN9 in cervical squa-mous cell carcinoma(CESC)through bioinformatics analysis based on The Cancer Genome Atlas(TCGA,TIMER 2.0,UALCAN)data and multiple online databases.Methods The cancer data set downloaded from UCSC database and TIMER 2.0 database were utilized to analyze the expression of TSPAN9 in pan-cancer.The expression and prognosis of TSPAN9 in CESC were analyzed using The UALCAN database,Human Protein Atlas(HPA)database,and Kaplan-Meier Plotter database.R software was used to analyze the correlation be-tween TSPAN9 and immune checkpoints,immune microenvironment and immune-infiltrating cells,as well as the enrichment of TSPAN9 in CESC were conducted using R software.Results TSPAN9 exhibited dysregu-lated expression across multiple cancer types,with notably low expression in CESC,which was closely related to the prognosis of CESC patients.TSPAN9 expression was associated with 45 marker genes of immunostimu-lantsand immunosuppressants,as well as significantly correlated with the infiltration of CD4+T cells,neutro-phils,macrophages,and dendritic cells in CESC.Gene Ontology(GO)enrichment analysis revealed that TS-PAN9 is involved in biological processes such as epithelial-mesenchymal transition and Wnt signal transduc-tion.Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis showed that TSPAN9 played a role in the TGF-β signaling pathway,p53 signaling pathway and other pathways in CESC.Conclusion The low expression of TSPAN9 in CESC has clinical significance for the prognosis of CESC patients,sugges-ting its potential as a novel target for cancer immunotherapy.
万方数据
维普
